Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2013 Jul 4;6(5):1236–1245. doi: 10.1242/dmm.012591

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2013. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

PMC Copyright notice

Fig. 4. — Therapy of REG3B–GLP-1 vector requires GLP-1 to maintain normoglycemia. (A) We generated an AAV9 vector expressing REG3B alone (AAV9 mRIP Reg3b). REG3B expression was verified by western blotting (left panel). Fasting blood glucose levels among mice administered PBS (control), AAV9 mRIP Reg3b–Glp-1 vector, and AAV9 mRIP Reg3b vector. AAV9 vector was administered 2 weeks prior to five consecutive STZ administrations (n=5/group), and the blood glucose levels were monitored. (B) The AAV9 mRIP Reg3b–Glp-1 vector was unable to reverse STZ-induced diabetes. Five low doses of STZ were administered prior to AAV9-mediated therapy (n=3/group). Error bars represent s.e.m.