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. 2013 May 29;6(5):1246–1259. doi: 10.1242/dmm.012005

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© 2013. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Fig. 2. — Transient reduction in OPCs in notch3 mutants at stages at which vessel patterning is intact. (A–C) olig2 at 50 hpf was similar in (A,A′) wild type and (B,B′) notch3^st51/+ heterozygotes, but was reduced in OPCs (compare red dashed areas) of (C,C′) notch3^st51/st51 mutants. Arrow indicates region devoid of olig2-expressing cells. (D–F) sox10 expression at 52 hpf was comparable in (D) wild type and (E) notch3^st51/+ heterozygotes, but was reduced in the midline of the hindbrain (compare yellow dashed areas) in (F) notch3^st51/st51 mutants. (A–C) Lateral views. (A′–C′,D–I) Dorsal views. (G–I) Vessel pattern at the anatomical level is intact in notch3^zm/zm mutants. Max projection images of Tg[fli1a:EGFP] labeled vasculature of (G) wild type (n=9), (H) notch3^zm/+ heterozygotes (n=9) and (I) notch3^zm/zm mutants (n=5). CtAs, central arteries; PHBC, primordial hindbrain channel; BA, basilar artery; MCeV, mid-cerebral vein; PCS, posterior connecting segment. The orientation of the anterior (A) and posterior (P) axis is indicated.