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. 2013 Sep 2;8(9):e72625. doi: 10.1371/journal.pone.0072625

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© 2013 Maranhão et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Selection fold changes were divided into strata, and the information content in each stratus is quantified for every residue using Weblogo. The size of the residue reflects a bias toward its presence in that specific position at specific strata. Positively selected V4 clones showed a large bias for the VQQVNNLA sequence, while negatively selected V4 clones display no clear bias for any HCDR3 sequence.

Inline graphic — Selection fold changes were divided into strata, and the information content in each stratus is quantified for every residue using Weblogo. The size of the residue reflects a bias toward its presence in that specific position at specific strata. Positively selected V4 clones showed a large bias for the VQQVNNLA sequence, while negatively selected V4 clones display no clear bias for any HCDR3 sequence.