Figure 5. Proposed model of NF-κB and p38 via C/EBPβ regulating the transcription of Tnfaip3 in LPS-induced response.

TLR4 engagement leads to activation of p38 MAPK and IKK/NF-κB. p38 MPAK subsequently through a yet-to-be-determined mechanism upregulates C/EBPβ, which induces A20 (TNFAIP3) transcription in conjunction with NF-κB.