Table 1. Top 10 enriched canonical pathways of the NF-κB and p38-dependent genes.

Rank	Ingenuity Canonical Pathways	−log(P-value)a	Genes
1	NF-κB signaling	3.64	Tnip1,Tnfaip3,Il1b,Tnfrsf1b
2	Granulocyte adhesion and diapedesis	3.62	Mmp14,Il1b,Tnfrsf1b,Fpr1
3	TNFR2 signaling	2.90	Tnfaip3,Tnfrsf1b
4	Hepatic fibrosis/hepatic stellate cell activation	2.67	Edn1,Il1b,Tnfrsf1b
5	Dendritic cell maturation	2.40	Il1b,Fcgr2b,Tnfrsf1b
6	TREM1 signaling	2.32	Il1b,Fcgr2b
7	IL-10 signaling	2.14	Il1b,Fcgr2b
8	Role of osteoblasts, osteoclasts and chondrocytes in rheumatoid arthritis	2.12	Mmp14,Il1b,Tnfrsf1b
9	Colorectal cancer metastasis signaling	2.03	Appl1,Mmp14,Rhou
10	PPAR signaling	1.90	Il1b,Tnfrsf1b

^aThe significance level of each canonical pathway was determined by in Ingenuity Pathway Analysis.