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. Author manuscript; available in PMC: 2014 Sep 1.

Published in final edited form as: Rheumatol Int. 2013 Mar 17;33(9):2301–2308. doi: 10.1007/s00296-013-2713-4

Arthritis scores of 8 week old wild-type C57BL/6 or MIF^−/− mice after administration of K/BxN serum (n=3 per genotype per time point). (a) Inflammation (hyperplasia of the synovial lining layer, exudation of granulocytes, infiltration of the synovial membrane by polymorphonuclear and mononuclear leukocytes, pannus formation) and (b) joint destruction (damage of articular cartilage surfaces and bone erosion) in mice with K/BxN serum-induced arthritis. The histologic scores for synovial inflammation and joint destruction are significantly less for MIF^−/− mice compared to the wild-type mice (P < 0.0004 and P = 0.004, respectively). Bars show the mean ± SEM. P values were determined by the Mann-Whitney U-test.

Arthritis scores of 8 week old wild-type C57BL/6 or MIF^−/− mice after administration of K/BxN serum (n=3 per genotype per time point). (a) Inflammation (hyperplasia of the synovial lining layer, exudation of granulocytes, infiltration of the synovial membrane by polymorphonuclear and mononuclear leukocytes, pannus formation) and (b) joint destruction (damage of articular cartilage surfaces and bone erosion) in mice with K/BxN serum-induced arthritis. The histologic scores for synovial inflammation and joint destruction are significantly less for MIF^−/− mice compared to the wild-type mice (P < 0.0004 and P = 0.004, respectively). Bars show the mean ± SEM. P values were determined by the Mann-Whitney U-test.