Serum cytokine levels following the administration of K/BxN serum into wild-type mice (WT), MIF−/− mice, MIF−/− mice reconstituted with wild-type macrophages (WT Mφ), and MIF−/− mice reconstituted with MIF−/− macrophages (MIF−/− Mφ). Serum samples (untreated: n=5, day 3 and 8: n=3) were examined for IL-1β, IL-6, TNF-α, MCP-1, IL-12(p40) and IL-10 levels using a Luminex-based assay. Bar show the mean and SEM. P values were determined by Student’s t-test (* P < 0.05).