Figure 2. Therapeutic and specific effect of Panobacumab on P. aeruginosa-induced pneumonia in immunosuppressed mice.

B6 mice were immunosuppressed with cyclophosphamide (100 mg/kg) and 3 days later infected by intra-nasal instillation of 40 µL of P. aeruginosa strain 2310.55 (2x10⁵ cfu). Panobacumab or a control anti-LPS: O1 IgM MAb (Ctrl O1 MAb, with specificity to serotype O1) were given i.v. at 0.4 mg/kg, 4 h after the infection. Lung cfu (A) and lung weight (B) were recorded 24 h after the infection. Groups of 14 mice were used and mean values ± SEM are shown (One-way ANOVA with Tukey’s Multiple Comparison Test; ns: non significant, * p<0.05, ** p<0.01, *** p<0.001). The results are a pool of two independent experiments.