Figure 5. Effect of Panobacumab on P. aeruginosa infection alone and in combination with antibiotic administration.

B6 mice received intra-nasal instillation of 40 µL of P. aeruginosa strain 2310.55 (10⁶ cfu). Meropenem or saline was given ip at 30, 100 and 300 mg/kg, 2 h after the infection. Lung cfu (A) and lung weights (B) were recorded 24 h after the infection. Panobacumab or a control anti-LPS: O1 IgM MAb (Ctrl O1 MAb, with specificity to serotype O1) were given i.v. at 0.4 mg/kg, 4 h after the infection, alone or in combination with Meropenem, lung cfu (C) and lung weight (D) and lung cfu (B) were recorded 24 h after the infection. Groups of 8-25 mice were used and mean values ± SEM are shown (One-way ANOVA with Tukey’s Multiple Comparison Test; ns: non significant, * p<0.05, ** p<0.01, *** p<0.001). The results are a pool of three independent experiments.