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. 2013 Sep 2;8(9):e74053. doi: 10.1371/journal.pone.0074053

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© 2013 Lertkiatmongkol et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(a) On the surface of the WT structure, helices C, D, and H are held by the network of hydrogen bonds indicated by black lines. The bonds are formed by guanidino group of R144 and carbonyl oxygen on the backbone of M136, R139, S140, and Q261. Such interactions are absent in R144C structure (b) due to a replacement of arginine to cysteine.