Figure 7. Deleting Vegfr2 in the myeloid lineage does not affect the development of the lymphatic vascular system.

(A,B) Whole-mount immunofluorescence staining of ear skin from Vegfr2^flox/flox and LysM^wt/Cre;Vegfr2^flox/flox mice for Lyve-1. (C) Quantitative analysis showing that the number of lymphatic branch points in the ear skin of Vegfr2^flox/flox (8.550±0.278, n = 5 mice) and LysM^wt/Cre;Vegfr2^flox/flox mice (9.150±0.5895, n = 5 mice) are not significantly different from one another. (D) Furthermore, lymphatic vessel diameter is not significantly different between Vegfr2^flox/flox (52.98 µm±1.328, n = 5 mice) and LysM^wt/Cre;Vegfr2^flox/flox mice (50.05 µm±2.031, n = 4 mice).