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. Author manuscript; available in PMC: 2013 Sep 2.
Published in final edited form as: Adv Neonatal Care. 2011 Jun;11(3):155–166. doi: 10.1097/ANC.0b013e31821baaf4

Table 3.

Distribution of Systemic Signs by Bell Staging [% of cases]

Nurse-Sensitive Assessments
(with definition)
All NEC patients
(n=117)
Stage I
(n=37)
Stage II
(n=28)
Stage IIIA
(n=15)
Stage IIIB
(n=37)
Temperature Instability
Temp ≤ 96.8°F (36°C) and/or ≥ 100.4°F (38°C)
14.7% 16.2% 7.4% 20% 16.2%
Bradycardia
HR < 100 beats/minute
54.3% 64.8% 66.7% 73.3% 27%
Severe apnea, requiring increase in
respiratory support
Greater ventilator support to maintain
oxygenation (i.e. increase in rate, transition
from CPAP to IMV)
49.6% 32.4% 46.4% 73.3% 59.5%
Administration of respiratory medications
initiated to support adequate oxygenation
Administration of caffeine, aminophylline or
theophylline
63.2% 78.4% 78.6% 60% 37.8%
Hypotension
Decrease in mean BP of more than 4 mm Hg
82.9% 73% 92.9% 86.7% 83.8%
Severe hypotension, requiring vasopressor
support
Administration of dopamine, dobutamine, or
epinephrine
17.1% 8.1% 14.3% 20% 27%
Respiratory acidosis
pH < 7.25 and CO2 > 60
46.7% 20.6% 47.8% 64.35 64.7%
Metabolic acidosis
TCO2 ≤ 18
11.9% 9.7% 13.6% 28.6% 5.9%
Thrombocytopenia
Platelets < 100,000
16.5% 15.6% 3.6% 14.3% 28.6%
Neutropenia
Neutrophils (polys) < 1,000
6.1% 16.2% 0 6.7% 0
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