FIG. 1.

Functional connectivity maps for the patients with panic disorder (A) and control healthy subjects (B) as measured by Fisher-transformed inter-voxel correlation coefficient projected on brain surface in Talairach space at p<0.01 (family-wise error corrected using Monte Carlo simulation), using seed region at the ACC (x=0, y=41, z=16, r=7mm) represented by a sky-blue-colored sphere in (C). The red color areas in the precuneus represent significant group difference at p<0.01 (family-wise error corrected using Monte Carlo simulation) (C). The region of interest positioned at the ACC (yellow line rectangular box) for the measurement of GABA concentration in a representative subject (D).