Table 1.

Sample characteristics by coronary artery plaque^* and white matter disease ^† (N=405)

Variable	Coronary Plaque Absent (n=231)	Coronary Plaque Present (n=174)	p-value	White matter disease volume ≤799 mm³ (median) (n= 203)	White matter disease volume >799 mm³ (median) (n=202)	p-value
Age (years)	47.3 ± 9.5	57.4 ± 8.9	<0.001	47.8 ± 9.8	55.5 ± 9.8	<0.001
Men	30.7%	53.4%	<0.001	41.9%	39.1%	0.57
African American	36.4%	35.1%	0.78	32.0%	39.1%	0.14
Hypertensive	30.3%	58.6%	<0.001	34.0%	51.0%	0.001
Diabetic	7.4%	16.1%	0.006	9.4%	12.9%	0.26
Current smoking	16.5%	20.1%	0.34	18.7%	17.3%	0.72
Statin therapy	34.3%	65.7%	<0.001	35.4%	64.7%	<0.001
LDL cholesterol (mg/dL)	114.1 ± 34.7	114.5 ± 40.1	0.91	117.3 ± 37.4	111.2 ± 36.5	0.10
HDL cholesterol (mg/dL)	60.3 ± 17.8	56.1 ± 17.3	0.02	57.8 ± 16.9	59.7 ± 18.6	0.28
Triglycerides (mg/dL)^‡	92.0 [66.0, 135.0]	103.0 [73.0, 151.0]	0.002	93.0 [70.0, 141.0]	95.0 [66.0, 138.3]	0.81
Body-mass index (kg/m²)	29.7 ± 5.9	30.3 ± 5.4	0.34	30.2 ± 5.8	29.7 ± 5.5	0.42
hsCRP (mg/dL)^‡	2.8 [1.1, 9.3]	2.3 [1.1, 7.9]	0.73	2.8 [1.2, 9.2]	2.3 [1.1, 7.8]	0.36

Coronary plaque defined by the presence of calcified or noncalcified plaque on computed tomographic angiography

^†

Continuous variables presented as mean ± 1 standard deviation

^‡

Non-normally distributed continuous variables presented as median [interquartile range]

HDL = High density lipoprotein

LDL = Low density lipoprotein