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Effects of novel CYP2C variation on warfarin dose prediction with the IWPC dosing algorithm
| Coefficient* | p value | Adjusted model R2† | |
|---|---|---|---|
| IWPC dosing equation Predicted Dose | .. | <2×10−16 | 0·2193 |
| rs12777823 AG | −6·92 | 6·76×10−6 | .. |
| rs12777823 AA | −9·34 | 0·00050 | .. |
| IWPC dosing equation and rs1277823 | .. | 1·7×106 | 0·2666 |
IWPC=International Warfarin Pharmacogenetics Consortium.
Represents change in warfarin dose (mg/week).
Increase indicates increase in amount of variability explained.
