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. Author manuscript; available in PMC: 2014 Sep 1.
Published in final edited form as: Nitric Oxide. 2013 May 14;0:18–41. doi: 10.1016/j.niox.2013.05.001

Fig. 5.

Fig. 5

Effects of 5,14-HEDGE and 20-HEDE on changes in NOS activity in (A) serum, (B) kidney, (C) heart, (D) thoracic aorta, (E) superior mesenteric artery measured 4 h after saline (vehicle) (4 ml/kg, i.p.) or LPS (10 mg/kg, i.p.) injection to conscious rats. 5,14-HEDGE (30 mg/kg, s.c.) and/or 20-HEDE (30 mg/kg, s.c.) were given 1 h after administration of saline or LPS. NOS activity in sera and tissue homogenates was measured by the rate of L-arginine to nitrite/nitrate conversion using the Ultrasensitive Colorimetric Assay for Nitric Oxide Synthase ELISA Kit following the manufacturer’s instructions. Data are expressed as means ± S.E.M of 4–6 animals. aSignificant difference from the corresponding value seen in rats treated with saline (p < 0.05). bSignificant difference from the corresponding value seen in the rats treated with LPS (p < 0.05). cSignificant difference from the corresponding value seen in the rats treated with LPS and 5,14-HEDGE (p < 0.05).