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. 2013 Aug 26;47(4):355–364. doi: 10.4132/KoreanJPathol.2013.47.4.355

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© 2013 The Korean Society of Pathologists/The Korean Society for Cytopathology

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Fig. 5 — Examples of interpretation issues in colorectal cancers. (A) Lymphovascular invasion (LVI) negativity with presence of thin fibrocollagenous layer between tumor cells and ERG-positive endothelial cells distinguishing from retraction artifact (100% concordance rate). (B) "Kissing pattern" showing tumor cells surrounded by endothelial nuclei interpreted as LVI positivity (87.5% concordance rate). (C, D) "Hugging pattern" highlighted by ERG immunostaining of endothelial nuclei embraced by tumor cells with unknown significance.