Table 7.

RSS differences specific to LTAAS when compared to (A) NSAC and (B) LTAA.

(A) LTAAS > LTAA
RSS with NAcc					LTAAS	LTAAS
	L/R	x	y	z	vs NSAC	vs LTAA
					p-value	p-value
Mid-posterior insula	R	42	−4	8	0.036*	0.001**
Thalamus	R	14	−17	11	0.642	0.006**
Caudate	R	16	3	13	0.518	0.001**
RSS with sgACC					LTAAS	LTAAS
	L/R	x	y	z	vs NSAC	vs LTAA
					p-value	p-value
Dorsolateral prefrontal cortex	L	−44	16	27	0.021*	0.001**
Caudate	L	−10	7	12 1	0.069	0.00004***
	R	15	19		0.334	0.0004***
Putamen	R	18	3	11	0.077	0.0001***
Anterior and mid-insula	L	−33	−5	18	0.151	0.0002***
(B) LTAAS > NSAC
RSS with NAcc					LTAAS	LTAAS
	L/R	x	y	z	vs NSAC	vs LTAA
					p-value	p-value
Cingulate	Middle	0	13	26	0.003**	0.099
Mid-posterior insula	L	−48	10	6	0.005**	0.310
	R	46	−1	12	0.004**	0.022*
RSS with sgACC					LTAAS	LTAAS
	L/R	x	y	z	vs NSAC	vs LTAA
					p-value	p-value
Dorsolateral prefrontal cortex	R	49	32	12	0.0002***	0.006**
Putamen	L	−21	18	−6	0.0004***	0.046
	R	25	−6	11	0.0054**	0.002**
Rostral ACC	L	−4	38	23	0.0019**	0.004**

LTAA, long-term abstinent alcoholics; LTAAS, long-term abstinent from alcohol and stimulants; RSS, resting state synchrony; NSAC, non-substance abusing controls; NAcc, nucleus accumbens; ACC, anterior cingulate cortex; L, left; R, right.

^*p < 0.05.

^**p < 0.01.

^***p < 0.001.