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CD4 T-cell responses of PBMCs from anti-CCP Ab/HLA-DRB1*04-positive RA patients to Fib-α R84Cit peptide. CD4 T cells from anti-CCP Ab/HLA-DRB1*04-positive RA patients (n=13) were stimulated with non-citrullinated (NP) and citrullinated (CP) fibrinogen peptides in the presence of APCs. Cell proliferation was quantified by the incorporation of BrdU (A). IFN-γ (B) and IL-17A (C) secretion was quantified from each peptide-stimulated culture supernatant by ELISA. ns=not significant.
