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Impaired induction of LTP at puberty: reversal by the stress steroid THP and δ knock-out. Theta burst stimulation (TBS—0 time) induced LTP (black) before puberty Pre-pub, (A) but not in the pubertal Pub, (B) CA1 hippocampus. THP (red, 30 nM) permitted LTP induction at puberty. (Inset, Representative field EPSPs. TBS, arrow. Scale, 0.5 mV, 50 ms.) (C). LTP, Pubertal δ−/−, where TBS induced LTP. n = 6–9/group. [Used with permission (Shen et al., 2010a)].
