Figure 4.

Impaired spatial learning of pubertal mice: reversal by the stress steroid THP and δ knock-out. (A) Spatial learning platform (shock zone, black sector). The platform rotates, but the shock zone is stationary, requiring the animal to move to actively avoid the shock. (B) Latency to first entry of the shock zone, a measure of learning. Pre-pub mice attained the longest entry times. (n = 6–9 mice/group) ^*P < 0.05 vs. pre-pub; ^**P < 0.05 vs. pub +/+ vehicle. [Revised and used with permission (Shen et al., 2007)].