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. 2013 Sep 3;7:135. doi: 10.3389/fncir.2013.00135

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Copyright © 2013 Smith.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Paradoxical anxiety-producing effects of THP in pubertal mice. Changes in anxiety produced by restraint stress or injection of THP (10 mg/kg, i.p.) are represented as a % change in open arm time in the elevated plus maze (EPM) compared to control values. In some cases the inactive 3β-OH isomer of THP (stress + 3β-OH-THP) or finasteride (a 5α-reductase inhibitor) were preadministered to test the role of THP release in the stress response. Replacement THP (10 mg/kg, i.p., in oil, for 3 d) was administered to prevent the decline in THP at puberty. n = 6–9 mice for each group. ^*P = 0.05 vs. control, ^**P = 0.05 vs. Pre-pub. [Used with permission (Shen et al., 2007)].