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. Author manuscript; available in PMC: 2013 Sep 3.

Published in final edited form as: Annu Rev Biochem. 2001 Nov 9;71:165–189. doi: 10.1146/annurev.biochem.71.110601.135352

TABLE 1.

Subunit composition of nuclear RNase P and RNase MRP from yeast (S. cerevisiae) and human cells

Yeast gene					Human gene

RNase P	RNase MRP	Subunit type	Molecular weight (kDa)^a	Isoelectric point (pI)^a	RNase P	RNase MRP	Archaeal RNase P	Reference
RPR1	—	RNA	120	—	H1	—	—	73, 79
—	NME1	RNA	112	—	—	7-2	—	168, 169
POP1	POP1	Protein	100.5	9.84	hPOP1	hPOP1	—	80, 86
POP3	POP3	Protein	22.6	9.57	—	—	—	81
POP4	POP4	Protein	32.9	9.26	RPP29^b	RPP29^b	MTH11	18, 82, 88
POP5	POP5	Protein	19.6	7.79	hPOP5	hPOP5	MTH687	1, 18, 89
POP6	POP6	Protein	18.2	9.28	—	—	—	1
POP7^c	POP7^c	Protein	15.8	9.34	RPP20	—	—	1, 85
POP8	POP8	Protein	15.5	4.57	—	—	—	1
RPP1	RPP1	Protein	32.2	9.76	RPP30	RPP30	MTH688	18, 83, 85
RPR2	—	Protein	16.3	9.99	RPP21	—	MTH1618	1, 18, 90
—	SNM1	Protein	22.5	9.81	—	—	—	156
—	—	Protein	—	—	RPP38^d	RPP38^d	—	85
—	—	Protein	—	—	RPP40^d	—	—	85
—	—	Protein	—	—	RPP25^d	—	—	85
—	—	Protein	—	—	RPP14^d	—	—	88

^a

Molecular weights are presented only for the yeast RNA and protein subunits. pIs are presented only for the yeast protein subunits.

^b

RPP29 is also known as hPOP4 (87).

^c

POP7 is also known as RPP2 (84).

^d

The relationship of these human proteins to the yeast protein subunits is currently unclear.