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. Author manuscript; available in PMC: 2013 Sep 3.
Published in final edited form as: J Neuropathol Exp Neurol. 2011 Mar;70(3):183–191. doi: 10.1097/NEN.0b013e31820c6878

FIGURE 5.

FIGURE 5

Mild traumatic brain injury (mTBI) causes dendrite degeneration. (A, B) Neurolucida reconstruction of Golgi-stained layers II/III neurons in the cortex of sham (A) and mTBI mice (B). (C, D) The total length (C) and the number of branches (D) of the dendrites in cells from sham and mTBI mice. The total length of the dendrites in spared neurons decreased from 1905 ± 357 to 508 ± 55 µm; branches are dramatically decreased from 32 ± 5 to 10 ± 1 in the cortex after mTBI (n = 5; *, p < 0.05). (E) Sholl analysis–derived distribution of layers II/III neuron dendritic complexity based on the distance from the cell body. Mean number of intersections of dendrite branches with consecutive 10-µm-spaced concentric spheres. (F) There is a dramatic reduction of dendritic complexity in the spared neurons in mTBI mice versus sham controls (n = 5; *, p < 0.05).

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