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. 2013 Jul 29;14(8):15724–15739. doi: 10.3390/ijms140815724

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© 2013 by the authors; licensee MDPI, Basel, Switzerland

This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).

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Cardiac levels of 2 markers of oxidative damage i.e., 8-oxo-7,8-dihydro-2′-deoxyguanosine (8-oxo-dG) (a), and telomere length (b), were measured with HPLC-ECD and real-time PCR, respectively. Key receptor for the glycation/inflammation pathway RAGE was measured on mRNA (c), and protein expression levels (d). Cardiac collagen levels in control (C), diabetic (D) and transgenic animals (DG) were visualized by Sirius red staining (e), and subsequently morphometrically quantified (f). *p < 0.05 compared with control, **p < 0.01 compared with control, ^#p < 0.05 compared with diabetes.