Table 1.
mRNA expression levels of genes involved in oxidative stress, DNA damage, inflammation and fibrosis. Values are given as percentage from control.
| Genes | Control | Diabetes | Diabetes + GLO-I |
|---|---|---|---|
| Oxidative stress | (C) | (D) | (DG) |
| SOD-3 | 100 ± 9 | 122 ± 9 | 91 ± 14 |
| CAT | 100 ± 10 | 226 ± 46 * | 190 ± 43 |
| GPX-1 | 100 ± 6 | 149 ± 12 * | 91 ± 12 # |
| NOX-4 | 100 ± 9 | 130 ± 9 | 97 ± 17 |
| DNA damage | - | - | - |
| p300 | 100 ± 6 | 116 ± 6 | 94 ± 16 |
| APEX-1 | 100 ± 1 | 121 ± 9 | 104 ± 8 |
| OGG-1 | 100 ± 6 | 121 ± 4 * | 129 ± 13 |
| p53 | 100 ± 25 | 133 ± 29 | 133 ± 33 |
| Inflammation | - | - | - |
| PAI-1 | 100 ± 13 | 278 ± 28 *** | 359 ± 46 *** |
| TNFα | 100 ± 12 | 126 ± 17 | 114 ± 17 |
| IL-1β | 100 ± 11 | 216 ± 26 * | 162 ± 28 |
| IL-6 | 100 ± 23 | 108 ± 19 | 93 ± 18 |
| Fibrosis | - | - | - |
| CTGF | 100 ± 13 | 180 ± 18 *** | 197 ± 23 |
| Col1α1 | 100 ± 13 | 65 ± 7 * | 109 ± 14 # |
| MMP-2 | 100 ± 6 | 78 ± 6 * | 115 ± 10 # |
| MMP-9 | 100 ± 23 | 150 ± 35 | 128 ± 22 |
*
p < 0.05 compared with control,
**
p < 0.01 compared with control,
***
p < 0.001 compared with control,
#
p < 0.05 compared with diabetes.