Figure 4.

Pericentrin signal variations during the cell cycle. Surrounding the centrioles, the pericentriolar material (PCM) provides a platform for emerging microtubules. In parallel with the cell cycle progression runs, a process known as centrosome maturation, where the PCM increases in size (mid-diagram and nucleus image) and finally splits (right diagram and nucleus image) to organize a bipolar mitotic spindle necessary for chromosome segregation between daughter nuclei. Red boxes mark γH2AX foci detected by the system and green boxes mark the detected pericentrin. Boxes are drawn by the system.