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. 2013 Jul 31;14(8):15959–15976. doi: 10.3390/ijms140815959

Figure 3.

Figure 3

Effect of DOR activation on cortical TrkB expression in hypoxia. (A) Representative blots of Western blot analysis of the cortical tissues; (B) Relative levels of 140 kDa TrkB. C, Relative levels of 90/140 kDa TrkB; (C) Normoxic control. H, Hypoxia. C + U (UFP-512), DOR activation with UFP-512 treatment under normoxic conditions. H + U (UFP-512), DOR activation with UFP-512 treatment under hypoxic conditions. N = 4, 5 and 6 for 1, 3 and 10 days groups, respectively. * p < 0.05 vs. the control. #p < 0.05 vs. C + U (UFP-512). &p < 0.05 vs. H + U (UFP-512). Note that 3 or 10 days hypoxia significantly reduced the level of 140 KDa TrkB and increased that of 90/140 kDa TrkB in the cortex, while DOR activation largely reversed these hypoxia-induced changes.