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. 2013 Jul 31;14(8):16040–16057. doi: 10.3390/ijms140816040

Figure 5.

Figure 5

(A) Relative mRNA level of p21 and Cyclin D in M21cells with Matrine treatment at concentration as indicated; (B) Protein expression of p21 and Cyclin D in M21cells with Matrine treatment at concentration as indicated; (C) Relative activity of caspases activity. Cells were incubated with Matrine at concentration, as indicated for 48 h before the activity was tested; (D) Relative mRNA level of Bcl-2 and Bax in M21cells with Matrine treatment at concentration as indicated; (E) Protein expression of Bcl-2, Bax, ERK1, ERK2 and p-ERK1/2pY204 in M21cells with Matrine treatment at concentration as indicated. Cells were incubated with Matrine at concentration as indicated for 48 h before performing Western blotting and real-time PCR. All data were expressed as means ± SD of three separate experiments. Significantly differences from control were indicated as *p < 0.05; **p < 0.01; ***p < 0.001.