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. 2013 Aug 7;14(8):16280–16302. doi: 10.3390/ijms140816280

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© 2013 by the authors; licensee MDPI, Basel, Switzerland

This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).

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miR repression determinants. Multiple factors determine repression effectiveness of miRs. These include: (a) Sequence complementarity at positions 2–7 or 2–8 of the 5′ end of the mature miR; (b) Target site features: binding site location near the edges of 3′ UTR or multiple binding sites for miRs; (c) Alternative cleavage and polyadenylation to maintain miR binding sites; (d) Relatively high miR levels; (e) Relatively low target levels; and (f) Presence of stabilizing and absence of destabilizing RNA binding protein sites.