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Measurement of collagen fibril diameter confirmed the smaller diameter fibrils in sedc/sedc mice shown in Figure 7. In the wild type the greatest abundance of fibrils measured between 30 and 50 nm, with some fibrils smaller than 30 and some greater than 50 nm, whereas in the mutant none were greater than 50 nm, some are in the 30 to 50 nm range but the highest percentage of fibrils was less than 30 nm diameter.
