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. 2013 Aug 14;14(8):16719–16731. doi: 10.3390/ijms140816719

Figure 2.

Figure 2

Enhanced sensitivity to OGD in the absence of PN-1. The role of PN-1 in cerebral ischemia was evaluated by subjecting mouse hippocampal slice cultures to OGD and measuring neuronal cell death in the CA1 by propidium iodide uptake. Mutant mice lacking one allele of PN-1 (heterozygotes, HET) were not significantly different from wild type mice (WT). In PN-1 knockout mice (KO) however, the amount of cell death was significantly higher than in wild types or heterozygotes (one-way ANOVA followed by Tukey-Kramer, p < 0.01). N represents the number of wells containing 3 to 5 slices each. (** p < 0.01).