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. 2013 Aug 16;14(8):16917–16942. doi: 10.3390/ijms140816917

Figure 1.

Figure 1

Angiotensin-converting enzyme (ACE) inhibition with captopril slowed Aβ plaque accumulation of Alzheimer’s disease (AD) mice. (a) Immunohistological analysis of Aβ plaque load in the hippocampus of a 12 month-old untreated Tg2576 mouse (Tg-12mo), an untreated 18 month-old Tg2576 mouse (Tg-18mo), and an 18 month-old Tg2576 mouse treated for six months with the centrally active ACE inhibitor captopril (Tg-18mo-ACEI); bar: 200 μm; (b) Quantitative assessment of hippocampal Aβ plaque area (±s.d., n = 4 mice/group; A,Bp < 0.001 vs. Tg-12mo; Cp < 0.01 vs. Tg-18mo; ANOVA and Tukey’s Multiple Comparison Test).