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. 2013 Aug 16;14(8):16917–16942. doi: 10.3390/ijms140816917

Figure 2.

Figure 2

Whole genome microarray gene expression profiling of hippocampal genes of AD mice. (a) Hippocampal whole genome microarray gene expression profiling of 18 and 12 month-old Tg2576 (Tg-18mo and Tg-12mo) mice without or with ACE inhibitor (ACEI) treatment by captopril for six months. Hippocampal RNA from four mice was pooled for one gene chip, and two gene chips are presented for each group; (b) Number of significantly different probe sets of 18 month-old captopril-treated Tg2576 mice compared to untreated 18 month-old Tg2576 mice with p ≤ 0.01, and ≥+2-fold (up) or ≤ −2-fold (down) difference; (c) The Venn diagram illustrates that more than 53% (i.e., 93 probe sets) of significantly increased hippocampal genes of 12 month-old Tg2576 mice compared to 18 month-old Tg2576 mice, showed concordant up-regulation in ACEI-treated 18 month-old Tg2576 mice.