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. 2013 Aug 16;14(8):16917–16942. doi: 10.3390/ijms140816917

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© 2013 by the authors; licensee MDPI, Basel, Switzerland

This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).

PMC Copyright notice

Captopril prevented the AD-related down-regulation of hippocampal genes involved in neuronal regeneration and cognition. A heat map visualizes signal intensities (log2-transformed data, centered to the median value) of significantly different probe sets of hippocampal genes involved in neuronal regeneration and cognition, which were down-regulated during Aβ plaque accumulation of 18 month-old Tg2576 mice and preserved by treatment with the ACE inhibitor (ACEI) captopril. Probe sets of 12 month-old Tg2576 mice are also shown to illustrate pre-treatment condition. Analysis of variance with p-values is presented as Table S5.