Table 1.
Patient characteristics of 9 patients with known mutations in BCR-ABL following the development of imatinib resistance.
| Patient | Age/Sex | Months on Imatinib until resistance |
HLA-A and -B alleles |
BCR-ABL Mutations |
|---|---|---|---|---|
| 1 | 64/M | 32 | A3, A11, B7, B52 | L150M, E255K, T315I, |
| 2 | 44/M | 6 | A2, A3, B7, B49 | E255K |
| 3 | 59/M | 2 | A2, A3, B7, B44 | E255K |
| 4 | 53/M | 6 | A2, A33, B37, B14 | E255K, T315I |
| 5 | 70/M | 1 | A1, A2, B8, B38 | M244V, E281K, T315A |
| 6 | 61/M | 14 | A2, A2, B40, B51 | G250E |
| 7 | 48/F | 2 | A1, A30, B18, B57 | V379I |
| 8 | 58/F | 7 | A1, A31, B7, B57 | T315I |
| 9 | 64/F | 33 | A1, A24, B8, B57 | E281K, G254R |