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. 2013 Oct;23(5):322–331. doi: 10.1089/nat.2013.0418

FIG. 7.

FIG. 7.

Effect of clones 2 and 9 on the intracellular cAMP concentration ([cAMP]i) in human granulocytes. Human granulocytes were incubated for 1 minute without (control) or with 1 μM ABA, without or with clone 2 or clone 9 at 2 or 20 μM. The [cAMP]i rise was calculated as the ratio between the [cAMP]i increase over control values in cells incubated with both ABA and aptamer, and the [cAMP]i increase over control values in cells incubated with ABA alone. Incubation of granulocytes with aptamer alone did not modify the [cAMP]i as compared to control values, at any of the concentrations tested. Forskolin was used as a positive control. Each condition was assayed in duplicate; results shown are the mean±standard deviation from 3 experiments. *p<0.05 compared with ABA 1 μM; **p<0.005 compared with ABA 1 μM, by t-test.