FIG. 6.
Transplantation of reprogrammed hDFs heterozygous into Akita mice results in decreased blood glucose levels. Cg-Rag1tm1Mom Ins2Akita Il2rgtm1Wjl/SzJ (NRG-Akita) female mice were transplanted with either three separate populations of hDFs, which were reprogrammed separately and transplanted into three mice (1.5×106 hDFs were infected with Pdx1 adenoviruses and 72 h later, 30 nM Romi and 1 μM 5-AzC were added for 48 h), or with control DFs. Blood glucose levels were measured before and postsurgery (surgery day=0). Values are the mean±S.E. from three separate mice. *, statistical significance with P<0.05 value, using a Student's t-test.