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Determination of the effect of α-lipoic acid alone or in combination with L-DOPA in the number of crossings in the open field test in animals pretreated with 6-OHDA. Eight animals per group were used. Values are expressed as mean ± S.E.M of the number of experiments. a versus control, b versus 6-OHDA, c versus 6-OHDA + LDOPA, d versus 6-OHDA + LA200, respectively; at P < 0.0001 (one-way ANOVA followed by Tukey's post hoc test).
