Table 1.

Association analysis of SNP genotypes in the French Case-Control cohorts with obesity using PLINK

	Genotype numbers and minor allele frequencies (MAF)												Results of association of SNP genotypes with obesity
	Controls				Morbidly obese adults				Severely obese children				Morbidly obese adults			Severely obese children
SNP	1,1a	1,2	2,2	MAF	1,1	1,2	2,2	MAF	1,1	1,2	2,2	MAF	Empirical P value	Corrected P value	Odds ratio (95% CI)	Empirical P value	Corrected P value	Odds ratio (95% CI)
rs33957861	874	254	21	12.9%	663	133	14	9.9%	482	121	8	11.2%	0.006	0.034 b	0.75 (0.61–0.91)	0.153	0.635	0.85 (0.69–1.06)
rs737477	1051	132	6	6.1%	449	56	1	5.7%	504	69	5	6.8%	0.716	1.000	0.94 (0.69–1.29)	0.382	0.945	1.14 (0.86–1.51)
rs2236318	319	568	223	45.7%	249	388	146	43.4%	176	282	124	45.5%	0.166	0.684	0.91 (0.8–1.04)	0.936	1.000	0.99 (0.86–1.15)
rs10823103	503	475	111	32.0%	378	311	66	29.3%	286	223	62	30.4%	0.086	0.430	0.88 (0.76–1.02)	0.348	0.924	0.93 (0.79–1.08)
rs12413112	876	238	22	12.4%	671	149	7	9.9%	457	119	7	11.4%	0.013	0.085	0.77 (0.63–0.95)	0.396	0.955	0.91 (0.73–1.13)
rs11599176	886	261	25	13.3%	684	156	8	10.1%	463	122	9	11.8%	0.003	0.019 b	0.74 (0.61–0.9)	0.217	0.767	0.87 (0.71–1.08)
rs10997865	480	511	129	34.3%	354	323	81	32.0%	249	264	71	34.8%	0.135	0.597	0.9 (0.78–1.03)	0.802	1.000	1.02 (0.88–1.18)
rs11596401	468	520	123	34.5%	339	329	70	31.8%	254	255	72	34.3%	0.083	0.443	0.89 (0.77–1.02)	0.936	1.000	0.99 (0.86–1.15)
rs35689145	948	187	9	9.0%	693	107	1	6.8%	526	80	4	7.2%	0.015	0.101	0.74 (0.58–0.94)	0.076	0.390	0.79 (0.61–1.03)
rs33955981	518	456	115	31.5%	389	333	76	30.4%	280	243	60	31.1%	0.474	0.984	0.95 (0.83–1.09)	0.830	1.000	0.98 (0.84–1.15)
rs2234975	952	220	7	9.9%	720	132	9	8.7%	499	75	6	7.5%	0.188	0.728	0.87 (0.7–1.07)	0.018	0.123	0.74 (0.57–0.95)

P values < 0.05 are shown in boldface.

Corrected P values result from one million permutations.

^a1 denotes the common allele and 2 denotes the rare allele.

^bStatistically significant P values.

CI, confidence interval.