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. 2013 Sep 3;7:139. doi: 10.3389/fncir.2013.00139

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Copyright © Kilb, Kirischuk and Luhmann.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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GABAergic currents during early development. (A) Whole-cell recordings from cells in ventricular zone of embryonic rats (E16) revealed dose-dependent GABAergic currents. (B) Photomicrograph of a biocytin-stained migrating neuron in a P1 rat. (C) Whole-cell recordings show that in migrating neurons a short (2–3 ms) application of 1 mM GABA (triangles) induced fast inward currents, while bath application of 1 μM muscimol induced a long lasting tonic current and led to a marked desensitization of phasic responses. The typical responses shown below the continuous trace are marked by asterisks. Pictures taken with kind permission from Owens et al. (1999) (A) and Heck et al. (2007) (B,C).