Table 2.

Size and Zeta potential analysis of liposomal preparations

	Liposome formulation*	Effective diameter in nm (PDI)†	Zeta Potential (mV)
Rhodamine liposomes for in vitro optical imaging	Non-PEG – 100	108 (0.074)	− 81 ± 7
	Non-PEG – 200	166 (0.059)	− 65 ± 2
	Non-PEG – 400	270 (0.177)	− 70 ± 4
	PEG – 100	103 (0.073)	− 36 ± 2
	PEG – 200	146 (0.111)	− 39 ± 2
	PEG – 400	218 (0.125)	− 39 ± 3
Liposomal-iodixanol for in vitro CT imaging	Non-PEG- 100	93 (0.067)	− 58 ± 3
	Non-PEG – 200	144 (0.115)	− 60 ± 2
	Non-PEG – 400	225 (0.121)	− 69 ± 2
	PEG – 100	98 (0.112)	− 37 ± 2
	PEG – 200	119 (0.108)	− 33 ± 2
	PEG – 400	153 (0.071)	− 33 ± 1
Liposomal-iodixanol for in vivo studies	IV-400	172 (0.1)	− 69 ± 1

^*the numbers 100, 200 and 400 indicate pore sizes of filter membranes through which the liposomes were extruded.

^†PDI is the poly-dispersity index of the particle sizes, defined as the ratio of the volume mean diameter to the number mean diameter.