. Author manuscript; available in PMC: 2014 Sep 1.

Published in final edited form as: Clin Colorectal Cancer. 2013 Jun 27;12(3):179–187. doi: 10.1016/j.clcc.2013.04.004

Table 1.

Treatment and Total Sample Size of Clinical Trials Included

Study Group	Clinical Trial	Control Arm	Experimental Arm	Total Sample Size
5-FU vs. surgery	NCCTG-78-48-52^a	Surgery	5-FU + LEV	247
	NCCTG-87-46-51^a	Surgery	5-FU + LV	408
	INT-0035^a	Surgery	5-FU + LEV	926
	FFCD^a	Surgery	5-FU + CF	256
	NCIC^a	Surgery	5-FU + CF	359
	SIENA^a	Surgery	5-FU + CF	239
	GIVIO^a	Surgery	5-FU + CF	846
	C01	Surgery	MOF	724
	C02	Surgery	PVI of 5-FU	896
5-FU vs. 5-FU variations	NCCTG-89-46-51	5-FU + LV × 1 y	5-FU + LEV × 6 mo; 5-FU + LEV + LV × 1 y; 5-FU + LEV + LV × 6 mo	915
	NCCTG-91-46-53	Standard dose; LEV + 5-FU + CF	High dose; LEV + 5-FU + CF	878
	S9415	5-FU + LV + LEV	CI 5-FU + LV	939
	C03	MOF	5-FU + LV	1042
	C04	5-FU + LV	5-FU + LV + LEV; 5-FU + LEV	2083
	C05	5-FU + LV	5-FU + LV + interferon	2136
	GERCOR	LV5FU2	FUFOL	902
	INT-0089	LEV	HDLV; LDLV; LEV + LDLV	3363
	QUASAR	5-FU + 175 mg L-folinic acid + placebo	5-FU + 25 mg L-folinic acid + placebo; 5-FU + 25 mg L-folinic acid + levamisole; 5-FU + 175 mg L-folinic acid + levamisole	3517
5-FU vs. 5-FU + oxaliplatin	MOSAIC^a	5-FU + LV	FOLFOX4	2241
	C07^a	5-FU + LV	FOLFOX	2434
5-FU vs. 5-FU + irinotecan	C89803	5-FU + LV	IFL	1264
	PETACC3	5-FU + LV	FOLFIRI	3188
5-FU vs. oral	XACT	5-FU + LV	Capecitabine	1986
	C06	5-FU + LV	Uracil/tegafur	1557

Abbreviations: 5-FU = fluorouracil; CF = cisplatin/5-FU; CI 5-FU = continuous infusion 5-FU; FOLFOX = 5-FU infusion/oxaliplatin/leucovorin; FUFOL = 5-FU bolus plus leucovorin; HDLV = high-dose leucovorin; IFL = 5-FU bolus/oxaliplatin/leucovorin; LDLV = low-dose leucovorin; LEV = levamisole; LV = leucovorin; MOF = semustine/vincristine/5-FU; PVI = protracted venous infusion.

The significant treatment effect differences were shown among the arms in original publications based on individual trial data.