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. Author manuscript; available in PMC: 2014 Jun 1.
Published in final edited form as: Circ Cardiovasc Genet. 2013 Jun;6(3):279–289. doi: 10.1161/CIRCGENETICS.113.000138

Figure 1.

Figure 1

Whole Exome Sequencing and Familial Genomic Triangulation for the Elucidation of a Novel Genetic Substrate for LQTS. (A) Black circles/squares are affected, grey are borderline, and white are unaffected with LQTS. Arrow identifies the proband. Asterisks represent those who were whole exome sequenced. Numbers in each circle/square represent QTc values (milliseconds) when available. Plus signs represent Pro857Arg-CACNA1C mutation positive family members. Minus signs represent mutation negative family members. NA denotes where DNA samples were not available. (B) Lead II of the electrocardiogram for the index case (III.2). The full electrocardiogram is available in Supplemental Figure 1A. (C) Schematic representation of our sequencing strategy. (D) DNA sequencing chromatogram showing the Pro857Arg mutation.