Figure 2.

Functional Analysis of Pro857Arg-Ca_v1.2 Mutation Using Whole Cell Patch Clamp Technique. (A) Representative I_Ca,L traces recorded from HEK293 cells expressing WT- or Pro857Arg-Ca_v1.2 along with auxiliary β_2cN4 and α₂δ₁ subunits. (B) Current-voltage (I–V) relations constructed from WT-Ca_v1.2 (■, n = 10) or Pro857Arg-Ca_v1.2 expressing cells (●, n = 10). Data were compared using Student’s unpaired t-test and * denotes p < 0.05 when WT-Ca_v1.2 was compared with Pro857Arg-Ca_v1.2.