Figure 1.

Structure-based design of peptides presenting the V3 loop of gp120 (A), and the three extracellular loops of CXCR4 (CX4-M1) (B). Peptides were designed based on crystal structures of a gp120–CD4 complex (pdb: 2b4c) and CXCR4 (pdb: 3odu), respectively.