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Binding of gp120 and V3 loop peptides from HIV-1 strains HxBc2 (+QR) and BAL (−QR), to mAbs 3869 and 447-52D (A). Dose-dependent effect of mAbs 447-52D and 3869, respectively, on binding of gp120HxBc2 (in the presence of sCD4) (B) and the respective V3 loop peptide (V3HxBc2) (C), to the CXCR4 mimetic peptide CX4-M1. See Section “Materials and Methods” (anti-V3 mAb ELISA and Competitive ELISA) for experimental detail. Error bars present deviations from the mean.
