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. Author manuscript; available in PMC: 2013 Nov 1.
Published in final edited form as: Dev Dyn. 2012 Sep 17;241(11):1695–1707. doi: 10.1002/dvdy.23857

FIGURE 7. Model.

FIGURE 7

7A) Transition from G1- to S-phase is at least in part dependent on the degradation of E2F1 in a replication dependent manner, thereby coupling the transcription of replication proteins to the initiation of replication (Shibutani et al., 2008).

7B) Reducing the levels of ORC5 might increase the distance between replication or slow the firing of replication origins. This would delay the degradation of DNA-bound and active E2F1, thereby prolonging the period of E2F1 dependent transcription, causing an increase in the levels of replication proteins available for the next cell cycle.