Figure 5. p53 C Terminus-Binding Surface of IFI16 HIN-A Domain.
(A) Transparent electrostatic surface representation of IFI16 HIN-A (left) and HIN-B (right) crystal structures. White, red, and blue colors correspond to neutral, negatively, and positively charged surfaces, respectively.
(B) Agarose EMSA of p53 (82–393) with wild-type or mutant IFI16 HIN-A (left). Molar ratio of p53 to HIN-A is 1:3. Surface representation of IFI16 HIN-A (right). Residues involved in binding are colored in magenta.