Table 1.

Affinity for cloned rat D_2L and D₃ receptors expressed in HEK293 cells measured by inhibition of [³H]spiperone binding

Compound	Ki (nM), rD2L [3H]spiperone	Ki (nM), rD3 [3H]spiperone	D2L/D3
(−)-5-OH-DPAT	58.8 ± 11.0	1.36 ± 0.28	43.2
Ropinirole	2,674 ± 305	29.3 ± 4.2	91.3
(+)-17 D-315c	40.6 ± 3.6	1.77 ± 0.42	22.9
(−)-15 D-237a	26.0 ± 7.5	0.825 ± 0.136	31.5
D-264b	264 ± 40	0.92 ± 0.23	253
D-301	269 ± 16	2.23 ± 0.60	121
D-440	1,073 ± 92	1.84 ± 0.51	583
9d	638 ± 40	22.2 ± 3.8	28.7
(+)-9d (D-515)	601 ± 98	20.2 ± 2.1	29.8
(−)-9d (D-516)	2,707 ± 178	45.5 ± 8.8	59.6
10a (D-261)	443 ± 57	19.7 ± 1.3	22.5
10b (D-262)	230 ± 25	112 ± 41	2.05
10c (D-263)	417 ± 93	195 ± 62	2.14
10f (D-311)	520 ± 22	54.1 ± 12.8	9.61
10d (D-312)	1,280 ± 218	60.0 ± 12.9	21.3
10e (D-314)	15,922 ± 3,820	1,790 ± 215	8.89
13 (D-355)	127 ± 2	10.7 ± 2.32	11.9
14a (D-357)	72.4 ± 7.3	4.13 ± 0.90	17.5
14b (D-358)	91.2 ± 6.1	8.64 ± 2.10	10.6
14c (D-359)	624 ± 54	109 ± 37	5.72
14d (D-360)	1,296 ± 322	174 ± 28	7.44
14e (D-397)	39.2 ± 6.1	3.69 ± 0.61	10.6
14f (D-401)	64.9 ± 12.0	2.22 ± 0.22	29.2
(+)-14f (D-532)	101 ± 10	2.32 ± 0.35	43.5
(−)-16b (D-399)	497 ± 214	17.6 ± 3.1	28.2
16a (D-400)	632 ± 264	32.0 ± 12.6	19.8
18 (D-398)	1,076 ± 375	26.9 ± 4.77	40.0

Results are the mean ± SEM for three to eight experiments, each performed in triplicate.

^aFrom our previous work (Ref. 22).

^bFrom our previous work (Ref. 21).

^cFrom our previous work (Ref. 25).